Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies. Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever.
It is orally administered for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility. Aceclofenac displays high permeability to penetrate into synovial joints where in patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation.Aceclofenac is also reported to be effective in other painful conditions such as dental and gynaecological conditions. Aceclofenac was developed as an analog of a commonly prescribed NSAID.
Indication of ACI-200
Aceclofenac Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
Side Effects
Common side effects are Somnolence, diarrhoea, heartburn, dyspepsia, nausea, vomiting, abdominal pain and flatulence.
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The description of ACI-200 (Aceclofenac 200mg SR) highlights its role as a highly effective non-steroidal anti-inflammatory drug (NSAID). This medication functions primarily by inhibiting the cyclo-oxygenase (COX) enzymes, which are crucial for the production of inflammatory prostaglandins. As a result, it aids in alleviating pain and reducing inflammation associated with various conditions, such as osteoarthritis, dental pain, and gynecological disorders.
Moreover, ACI-200's ability to penetrate synovial joints makes it particularly beneficial for patients experiencing joint pain. By mitigating the inflammatory responses in these areas, the medication helps restore mobility and relieve discomfort. This dual action of providing both analgesic and anti-inflammatory benefits sets ACI-200 apart in the broad category of pain management therapies.
Benefits of ACI-200
ACI-200 provides numerous benefits to patients requiring relief from pain and inflammation. Its primary advantage lies in its targeted action against inflammatory conditions, offering relief for those suffering from chronic joint pain related to osteoarthritis. The consistency of the medication's effects over time also helps in managing acute episodes of pain more effectively than many alternatives.
Furthermore, patients report a high level of satisfaction due to the rapid onset of its analgesic properties, allowing them to resume daily activities with minimal disruption. The medication’s formulation supports prolonged release, ensuring that its beneficial effects last longer, thus improving overall patient compliance when managing chronic pain conditions.
Side Effects
While ACI-200 is effective for many, it is important to be aware of its potential side effects. Common side effects include somnolence, gastrointestinal disturbances such as heartburn, nausea, and vomiting. These reactions underline the necessity for patients to communicate openly with their healthcare providers about any adverse effects they encounter during treatment.
In some cases, the side effects may require adjustments in dosage or discontinuation of the medication altogether. Patients should remain vigilant and report significant or persistent side effects to ensure safe and effective use of ACI-200. Understanding the risk-benefit ratio is paramount for making informed decisions regarding usage of this medication.
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