ACILET-PLUS (Aceclofenac 100mg,Paracetamol 325mg,Thiocolchicoside 4mg)

Product Introduction of Acilet-Plus

• Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies.
• Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It is orally administered for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility.
• Aceclofenac displays high permeability to penetrate into synovial joints where in patients with osteoarthritis and related conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation. Aceclofenac is also reported to be effective in other painful conditions such as dental and gynaecological conditions. Aceclofenac was developed as an analog of a commonly prescribed NSAID.
• Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it. Paracetamol is a common painkiller used to treat aches and pain. Paracetamol can also be used to reduce a high temperature.

Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. Thiocolchicoside acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. Thiocolchicoside has powerful convulsant activity and should not be used in seizure-prone individuals.

Indication of Acilet-Plus

• Aceclofenac Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
• Paracetamol For temporary relief of pain.
• Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects.
• Thiocolchicoside acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent.
• Thiocolchicoside has powerful convulsant activity and should not be used in seizure-prone individuals

Side Effects

• Common side effects are Somnolence, diarrhoea, heartburn, dyspepsia, nausea, vomiting, abdominal pain and flatulence.