Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine. Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate .
Trypsin also contains an oxyanion hole that stabilizes the charge negative charge on the carbonyl oxygen atom formed from the cleavage of peptide bonds. Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.
Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors . It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement. Rutoside, a herbal analgesic for effective pain relief.
Indications of CHEMLET
Trypsin & Bromelain, proteolytic enzymes that clears dead cells to reduces pain and inflammation and Rutoside, a herbal analgesic for effective pain relief.
CHEMLET tablets are used to treat pain and inflammation related to osteoarthritis, rheumatoid arthritis, and tendonitis.
It is also used to treat conditions such as edema and inflammation following surgeries of cellulitis, sports injuries, tooth extractions, and sprains..
Side Effects
Common side effects are temporary stinging sensation, nausea, hives, difficulty in breathing, burning sensations, Indigestion and loss of balance.
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